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She had been diagnosed with RA (ANA+, RF+, CCP-) two years earlier and treated with renally dosed MTX (10 mg) weekly and daily folic acid supplementation with a 1 mg dose

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Higgins JPT, Thomas J, Chandler J et al (2021) Cochrane handbook for systematic reviews of interventions version 6.2 Sterne JAC, Savovi J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomized trials

Une carence en B12 peut se manifester par : fatigue, fourmillements dans les mains et les pieds, troubles de la mmoire, pleur ou irritabilit

If severe B12 deficiency with neurological involvement is suspected, treatment should be initiated promptly without waiting for test results, and specialist advice may be needed